a. Heavy chain V_H-D_H-J_H rearrangement begins in the pre-B cell stage.

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b. Immature B cells express membrane IgM and IgD.

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c. The enzyme terminal deoxyribonucleotidyl transferase (TdT) is active in the pre-B cell stage.

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d. The surrogate light chain is expressed by pre-B cells.

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e. Self-reactive B cells can be rescued from negative selection by the expression of a different light chain.

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f. In order to develop into immature B cells, pre-B cells must interact directly with bone-marrow stromal cells.

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g. Most of the B cells generated every day never leave the bone marrow as mature B cells.

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