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PCB 4233C Immunology

Matching/Definitions/Terms

Chapter 7  
Select the description(s) listed below (1-11) that are true about each of the terms (a-h). Each description may be used once, more than once, or not at all; more than one description may apply to some terms. You can utilize your book or link to Resources for help.   If there are descriptions which you do not use, find the term that you believe the description is associated with.

Print this page and fill in  your answers--be prepared to discuss items in class.

Terms

Description

Answer

a. Rag-1 and RAG-2

1. Junctions between immunoglobulin gene segments formed during rearrangement

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b.Double-strand break repair (DSBR) enzymes

2.  Source of diversity in antibody heavy chains

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c. Coding joints

3.  DNA regulatory sequences

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d.  RSSs

4. Conserved DNA sequences, located adjacent to V, D, and J segments, that help direct gene rearrangement

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e. P-nucleotides

5. Enzymes expressed in developing B cells

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f. N-nucleotides

6.  Enzymes expressed in mature B cells

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g. Promoters

7. Nucleotide sequences located close to each leader segment in immunoglobulin genes to which RNA polymerase binds

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h. Enhancers

8.  Product of endonuclease cleavage of hairpin intermediates in Ig-gene rearrangement

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9.  Enzymes that are defective in SCID mouse

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10. Nucleotide sequences that greatly increase the rate of transcription of rearranged immunoglobulin genes compared with germ-line DNA

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11. Nucleotides added by TdT enzyme

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