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PCB 4233C Immunology

Matching/Definitions/Terms

Chapter 5  
For each type of cell indicated (a-e), select the most appropriate description (1-13) that are true about that isotype. Each description may be used once, more than once, or not at all; more than one description may apply to some isotypes. You can utilize your book or link to Resources for help. If there are descriptions which you do not use, find the term that you believe the description is associated with.

Print this page and fill in  your answers--be prepared to discuss items in class.

Isotypes

Description

Answer

a. IgA

1. Secreted form is a pentamer of the basic H2L2 unit

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b.IgD

2.  Binds to Fc receptors on mast cells

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c. IgE

3.  Multimeric forms have J chain

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d.  IgG

4. Present on the surface of mature, unprimed B cells

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e. IgM

5. The most abundant isotype in serum

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6.  Major antibody in secretions such as saliva, tears, and breast milk

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7.  Present on the surface of immature B cells

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8.  The first serum antibody made in a primary immune response

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9.  Plays an important role in immediate hypersensitivity

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10. Plays an important role in protecting against pathogens that invade through the gut or respiratory mucosa

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11. Multimeric forms may contain a secretory component

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12. Can fix complement by the classical pathway

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13. Least abundant isotype in serum

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