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PCB 4233C Immunology

Matching/Definitions/Terms

Chapter 4  
For each of the following statements, indicate whether it is true only of B-cell epitopes (B), only of T-cell epitopes(T), or Both types of epitopes (BT) within a large antigen. You can utilize your book or link to the Resources for more information.  

Print this page and fill in  your answers--be prepared to discuss items in class.

Statement

Answer

(B, T, BT)

a. They always consist of a linear sequence of amino acid residues.

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b. They generally are located in the interior of a protein antigen.

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c. They generally are located on the surface of a protein antigen.

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d. They lose their immunogencity when a protein antigen is subjected to heat denaturation.

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e. Immunodominant epitopes are determined in part by the MHC molecules expressed by an individual.

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f. They are present only in protein antigens.

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g. Multiple different epitopes may occur in the same antigen.

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h. Their immunogenicity may depend on the three-dimensional structure of the antigen.

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i. The immune response to them may be enhanced by co-administration of Freund's complete adjuvant.

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