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Terms
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Statement
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| Protein phosphatase(s) |
a. Fyn and ZAP-70 are _____________associated with the
cyoplasmic domains of ____________ |
| Protein kinase(s) |
b. __________ is a T-cell membrane protein that has cytosolic
domains with phosphatase activity. |
| phospholipase(s) |
c. Dendritic cells express ____________constitutively,
whereas B cells must be activated before they express this membrane molecule. |
| class I MHC |
d. Calcineurin, a ____________, is involved in generating
the active form of the transcription factor NF-AT. |
| class II MHC |
e. Activation of TH cells results in secretion
of __________ and expression of its receptor, leading to proliferation
and differentiation. |
| IL-2 |
f. The co-stimulatory signal needed for complete TH-cell
activation is triggered by interation of _________on the T cell and ____________
on the APC. |
| CD8 |
g. Knockout mice lacing class I MHC molecules fail to produce
thymocytes bearing ______________. |
| CD4 |
h. Macrophages must be activated before they express __________
molecules and ____________ molecules. |
| CD28 |
i. T cells bearing _____________ are absent from the lymph
nodes of knockout mice lacking class II MHC molecules. |
| CD45 |
j. PIP2 is split by a __________ to yield DAG
and IP3. |
| B7 |
In activated TH cells, DAG activates a ___________
which acts to generate the transcription factor NF-kB |
| IL-6 |
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