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Schedule

Week of: Jan 7 Jan 10-14 Jan 16-22 Jan 23-29 Jan 30-Feb 5 Feb 6-12 Feb 13-19 Feb 20-26 Feb 27-Mar 3
March 5-11 Mar 12-18 Mar 19-25 Mar 26-Apr 1 Apr 2-8 Apr 9-15 Apr 16-22 Apr 24 May 1

 
Module 1: January 7
Teleconference
Teleconferences will start January 16		 Readings
Tortora: Chapter 3
Hudson: pp. 3-4		 Lab: January 7
Course Introduction, General Laboratory Practices and Safety, Lab Protocol and Reports
Video: Introduction to the Microscope
CD-ROM: Microscopy Tutor
Hudson: Exericises 1 and 11


Module 2: January 10 - 14
Teleconference
Teleconference will start next week		 Readings:
Tortora: Review Chapter 2		 Lab: January 14
Whitaker Hall Ground Breaking: 9:00-9:30
Hudson: Exercises 2, 3 & 5


Module 3:  January 16 - 22
Teleconference 1
January 16, 2:00 pm
The Microbial Universe		 Readings:
Tortora: Chapter 1 and selected readings from Study Guide		 Lab: January 21
Gram Stain Tutor
Hudson: Exercises 7 & 8
Objectives:
    Upon completion of this module, the student will: 
    1. List several ways in which microorganisms affect our lives
    2. Identify the contributions and the importance of the findings of 
        Hooke, Leeuwenhoek, Needham, Spallanzani, Virchow, 
        Pasteur, Lister, Koch, Ehrlich, Fleming and Dubos.
    3. Define bacteriology, mycology, parasitology, immunology and 
        virology.
    4. Recognize the system of scientific nomenclature.
    5. List the major characteristics of bacteria, fungi, protists, plants and 
        animals.
    6. Differentiate among the major groups of organisms studied in 
        microbiology.
    7. List at least 4 beneficial and 4 deliterious activities of microorganisms.
    8. List two examples of biotechnology.
    9. Define normal microbiota and give 2 examples of normal flora of 
        humans.


Module 4: January 23 - 29
Teleconference 2
January 23
The Unity of Living Systems		 Readings:
Tortora; Chapter 4 and selected readings from telecourse guide		 Lab: January 28
Hudon; Exercises 6 & 9
Objectives:
    Upon completion of this module, the student will:
      1. Compare and contrast the overall cell structure of prokaryotes and 
          eukaryotes.
      2. Identify the three basic shapes of bacteria.
      3. Describe the structure and function of the glycocalyx, flagella, axial 
          filaments, fimbriae and pili.
      4. Compare and contrast the cell wall of Gram positive bacteria, Gram 
          negative bacteria, archaea and mycoplasma. 
      5. Describe the structure, chemistry and functions of the prokaryotic 
          plasma membrane.
      6. Define simple diffusion, osmosis, facilitated diffusion, active 
          transport and group translocation.
      7. Identify the functions of the nuclear area, ribosomes and inclusions.
      8. Define organelle and describe the functions of the nucleus, 
          endoplasmic reticulum, ribosomes, Golgi complex, mitochondria, 
          chloroplasts, lysosomes and centrioles.
      9. Discuss evidence that supports the endosymbiotic theory of 
          eukaryotic evolution.
    10. Differentiate between a virus and a bacterium.
    11. Describe the chemical composition and structure of an enveloped 
          and nonenveloped virus.
    12. Compare and contrast the multiplication cycle of DNA and RNA 
          containing viruses


Module 5: January 30 - February 5
Teleconference 3
January 30
Metabolism		 Readings:
Tortora: Chapter 5 and selected readings		 Lab: February 4
Hudson: Exercises 12 & 14
Objectives:
    Upon completion of this module, the student will:
      1. Define metabolism, anabolism and catabolism.
      2. Identify the role of ATP in metabolism.
      3. Describe the mechanism of enzymatic action.
      4. List the factors that influence enzymatic activity.
      5. Explain the overall function of metabolic pathways.
      6. Describe the chemical reactions of glycolysis.
      7. Explain the products of the Kreb's cycle.
      8. Describe the models for ATP generation.
      9. Compare and contrast aerobic and anaerobic respiration.
    10. Describe the chemical reactions of and list some of the products of 
          fermentation.
    11. Provide an example of the use of biochemical tests to identify 
          bacteria.
    12. Describe the process of photosynthesis.
    13. Categorize the various nutritional patterns among organisms 
          according to carbon source and mechanisms of carbohydrate 
          catabolism.
    14. Distinguish between chemically defined and complex media.
    15. Describe the use of anaerobic techniques, gas incubators, living host 
          cells, selective, differential and enrichment media in the isolation 
          and identification of microorganisms.
    16. Describe how pure cultures can be isolated.
    17. Define bacterial growth, binary fission and generation time.
    18. Compare primary, secondary and tertiary sewage treatment.
    19. List some of the biochemical activities that take place in an sludge 
          digester.
    20. Define activated sludge system, trickling filter, septic tank and 
          oxidation pond.


Module 6: February 6 - 12
Teleconference 4
February 6
Reading the Code of Life		 Readings:
Tortora: Chapter 8 and selected readings		 Lab: February 11
Exam 1: Teleconference 1-3 & readings
Hudson: Exercise 16
Objectives:
    Upon completion of this module, the student will:
    1. Define genetics, chromosome, gene, genetic code, genotype and 
        phenotype.
    2. Describe how DNA serves as genetic information.
    3. Describe the process of DNA replication.
    4. Describe protein synthesis including transcription and translation.
    5. Explain the regulation of gene expression in bacteria by induction, 
        repression and catabolite repression.
    6. Classify mutations by type and describe hoe mutations are prevented 
        or repaired.
    7. Discuss how genetic mutation and recombination provide material for
        natural selection.


Module 7: February 13 - 19
Teleconference 5
February 13
Genetic Transfer		 Readings:
Tortora: Chapter 9, 13, 28 and selected readings		 Lab: February 18
Hudson: Exercise 18 and handout
Pick up water sample kit for next week
Objectives:
    Upon completion of this module, the student will:
      1. Compare th emechanisms of genetic recombination in bacteria.
      2. Relate the mechanisms for genetic change to microbial evolution.
      3. Describe the functions of plasmids and transposons.
      4. Discuss how genetic mutations and recombination provide material 
          for natural selection.
      5. Compare and contrast genetic engineering, recombinant DNA and 
          biotechnology.
      6. Identify the roles of a clone and a vector in genetic engineering.
      7. Define restriction enzymes and decribe how they are used.
      8. List properties of vectors.
      9. Describe the use of plasmid and viral vectors.
    10. Describe five ways of getting DNA into a cell.
    11. Describe how a gene library is made.
    12. Differntiate between cDNA and synthetic DNA.
    13. Explain how each of the following is used to locate a clone:
           antibitic resistanc egene, DNA probes and gene product.
    14. List five applications of genetic engineering.
    15. List the advantages and problems associated with genetic 
          engineering.
    16. Describe the role of microorganism in the production of chemicals 
          and pharmaceuticals.


Module 8: February 20 - 26
Teleconference 6
February 20
Microbial Evolution		 Readings:
Tortora: Chapter 10 and selected readings		 Lab: February 25
No Campus Lab
Off Site Water Sampling 
Objectives:
    Upon completion of this module, the student will:
    1. Define taxon, taxonomy and phylogeny.
    2. Discuss the limitations of the two kingdom system of classification.
    3. List the characteristics of the Bacteria, Archaea and Eukarya domains.
    4. Differntiate among eukaryotic, bacterial and viral species.
    5. Describe how staining and biochemical tests are used to identify 
        bacteria.
    6. Describe how serological and molecular techniques are used to classify 
        microorganisms.


Module 9: February 27 - March 3
Teleconference 7
February 27
Microbial Diversity		 Readings:
Tortora: Chapter 5, 6 and selected readings		 Lab: March 3
Hudson: Exercises 19 & 20		 Note: March 3 is the last day to withdraw without academic penalty
Objectives:
    Upon completion of this module, the student will: 
    1. Outline the polymerase chain reaction and give an example of its use.
    2. Classify microorganism on the basis of preferred temperature range.
    3. Explain the importance of pH and osmotic pressure to microbial 
        growth.
    4. Explain how microbes are classified on the basis of oxygen 
        requirements.
    5. Identify ways in which a microbe avoid damage by toxic forms of 
        oxygen.
    6. Describe how an ecological community can exist without light energy. 


Module 10: March 5 - 11 Spring Break
No Teleconference This Week No Laboratory This Week


Module 11: March 12 - 18
Teleconference 8
March 12
Microbial Ecology		 Readings:
Tortora: Chapter 27 and selected readings		 Lab: March 17
Exam 2: Teleconference 4-7 and readings
Hudson: Exercises 25 & 26
Objectives:
    Upon completion of this module, the student will: 
    1. Define biogeochemical cycle.
    2. Outline the carbon cycle and explain the role of microorganism in 
        this cycle.
    3. Outline the nitrogen cycle and explain the role of microorganism in 
        this cycle.
    4. Define amonification, nitrification, denitrification and nitrogen 
        fixation.
    5. Define bioremediation.
    6. Give two examples of the use of bacteria to remove pollutants.
    7. Describe the freshwater and seawater habitats of microorganisms.
    8. Define BOD.


Module 12: March 19 - 25
Teleconference 9
March 19
Microbial Control		 Readings:
Tortora: Chapter 7, 20 and selected readings		 Lab: March 24
Hudson: Exercises 13 & 29
Objectives:
    Upon completion of this module, the student will:
      1. Define the following terms related to microbial control: sterilization, 
          disinfection, antisepsis, germicide, bacteriastasis, asepsis and 
          sanitation.
      2. Compare the effectiveness of moist heat and dry heat on 
          microorganisms.
      3. Describe how filtration, low temperatures, dessication and osmotic 
          pressure suppress microbial growth.
      4. Explain how radiation kill cells.
      5. List the factors related to effective disinfection.
      6. Identify the methods of action and preferred uses of chemical 
          disinfectants.
      7. Differentiate between halogens used a antiseptics and as 
          disinfectants.
      8. Identify the appropriate uses for surface-active agents.
      9. List the advantages and disadvantages of using glutaraldehyde over 
          other chemical disinfectants.
    10. Identify methods of sterilizing plastic labware.
    11. Describe the problems of chemotherapy for viral, fungal, protozoan 
          and helminthic infections.
    12. Identify five modes of action of antimicrobial drugs and give an 
          example of each.
    13. Describe two tests for microbial susceptibility to chemotherapeutic 
          agents.
    14. Describe mechanisms of drug resistance.
    15. Compare and contrast synergism and antagonism.
    16. Compare and contrast food preservation by industrial food canning, 
          aseptic packaging and radiation.


Module 13: March 26 - April 1
Teleconference 10
March 26
Microbial Interactions		 Readings:
Tortora: Chapters 12, 14 25 & 27		 Lab: March 31
Hudson; Exercises 27 & 28
Objectives:
    Upon completion of this module, the student will:
    1. List the defining characteristics of fungi.
    2. Differentiate between asexual and sexual reproduction, and 
        describe each of these processes in fungi.
    3. List the defining characteristics of algae.
    4. List the distinguishing characteristics of lichens.
    5. Define normal, transient and opportunistic microbiota.
    6. Compare commensalism, mutualism and parasitism, and give an 
        example of each.
    7. Define mycorrhiza.
    8. Define symbiosis, parasitism and mutualism.
    9. Define bioremediation.


Module 14: April 2 - 8
Teleconference 11
April 2
Human Defenses		 Readings:
Tortora: Chapter 15, 16, 17 18 & 19		 Lab: April 7
Exam 3: Teleconference 8-10 and readings
Hudson; Exercises 30, 31 & 32
Objectives:
    Upon completion of this module, the student will: 
      1. Describe the structure of the skin and mucous membranes and the 
          ways pathogens can adhere to and invade the skin.
      2. Provide examples of normal skin flora.
      3. Define LD50
      4. Explain how capsules and cell wall components contribute to 
          pathogenicity.
      5. Contrast the nature and effects of exotoxins and endotoxins.
      6. Differentiate betwwen mechanical and chemical natural host 
          defense mechanisms.
      7. List the five different types of white blood cells and list their 
          function.
      8. List the stages of inflammation.
      9. Describe the roles of vasoactive mediators in inflammation and list 
          examples.
    10. Define the cause and effects of fever.
    11. List the components of the complement system.
    12. Describe two pathways of activating complement.
    13. Describe the consequences of complement activation.
    14. Define interferon and compare and contrast the actions of alpha, 
          beta and gamma interferons.
    15. Differentiate between specific and nonspecific immunity.
    16. Contrast the four types of acquired immunity.
    17. Differentiate between humoral and cell-mediated immunity.
    18. Define antigen and antibody.
    19. Explain the functions of antibodies and describe their structural 
          and chemical characteristics.
    20. List one function for each of the five antibody classes.
    21. Describe the clonal selection theory.
    22. Distinguish between a primary and secondary immune response.
    23. Compare and contrast T and B lymphocytes.
    24. Compare and contrast T-dependent and T-independent antigens.
    25. Describe the role of antibodies and NK cells in antibody-dependent
          cell-mediated cytotoxicity.
    26. Define vaccine and explain why vaccination works.
    27. Define herd immunity.
    28. Compare and contrast between the following and give an example 
          of each: attenuated, inactivated, toxoid, subunit, conjugated, 
          recombinant and DNA vaccines.


Module 15: April 9 - 15
Teleconference 12
April 9
Microbes and Human Disease		 Readings:
Tortora: Chapter 14, 21-26 		 Lab: April 14
Hudson: Exercises 32, 33, 23 & 24
Objectives:
    Upon completion of this module the student will:
      1. List Koch's postulates
      2. Differentiate between a communicable and a non communicable 
          disease.
      3. List notifiable diseases.
      4. Categorize diseases according to frequency of occurrence and 
          severity.
      5. List five probabale reasons for emerging infectious diseases and 
          give an example of each.
      6. Define reservoir of infection.
      7. Contrast human, animal and nonliving reservoirs and give an
          example of each.
      8. Describe four methods of disease transmission.
      9. Define nosocomial infections and explain their importance.
    10. Identify four predisposing factors for infectious disease.
    11. Define epidemiology and describe three types of epidemiologic 
          investigations.
    12. Contrast morbidity and mortality in relation to infectious diseases. 


Module 16: April 16 - 22
Teleconference
Teleconference Wrap up and Discussion of Series "Unseen Life on Earth" 		 Lab: April 21
Hudson: Exercises 23 & 24


Module 17: April 24
Special Projects: All papers and special projects are due this week. Lab: April 21
Bacterial Unknowns
Hudson: Exercise 11
Lab Wrap Up


Module 18: May 1
May 1: Exam # 4: Monday 2:00 - 4:00 pm (teleconference 11 & 12 and readings) 

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